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451 4.4.0 primary outbound frontend ip address responded with exchange 2013

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I am facing an issue some of the receipients in exchange 2013 :: 451 4.4.0 primary outbound frontend ip address responded with: "450 4.7.0 proxy session setup failed on frontend with '451 4.4.0 Error encountered while communicating with primary target ip address "451 4.4.0 Socket error SocketError." Attempted failover to alter

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